Topics of Interest

How do Fibroids Cause Infertility and Heavy Menstrual Bleeding?

Leiomyoma simultaneously impair endometrial BMP-2-mediated decidualization and anticoagulant expression through secretion of TGF-β3.

Journal: Journal of Clinical Endocrinology and Metabolism. 2011;96:412-21.

Authors: Sinclair DC, Mastroyannis A, Taylor HS.

Study from: Yale University School of Medicine

Problem: Women with submucous fibroids have decreased fertility, increased miscarriage rates, and heavy menstrual bleeding. Why this happens has not been well understood. The authors tested to see if proteins that interfere with fertility and/or cause heavy bleeding were produced by fibroids.

Study: Sophisticated laboratory tests were performed on fibroids and normal uterine muscle to see if the cells made proteins that could cause infertility or heavy bleeding.

Results: Fibroids make different amounts of proteins than normal uterine muscle and these proteins make it more difficult for a fertilized egg to stick to the uterine lining. Fibroids also make other proteins that interfere with the blood clotting in the uterine lining which causes heavy bleeding.

Dr. Parker’s Comments: This is cutting edge science from the fertility group at Yale. Using techniques from molecular biology, the authors showed that fibroids make proteins that both decrease fertility and increase menstrual bleeding. We knew these effects existed, but now we have a better idea as to why.





Disclaimer: The ideas, procedures and suggestions contained on this web site are not intended as a substitute for consulting with your physician. All matters regarding your health require medical supervision.

Fibroid Doctor William H. Parker

Dr. William H. Parker is a board-certified Fellow in the American College of Obstetricians and Gynecologists. Dr. Parker is an internationally recognized expert in fibroid surgery and research. Based in San Diego, California, he is considered one of the best fibroid surgeons for abdominal and laparoscopic myomectomy in the United States and abroad. He has been chosen for Best Doctors in America and Top Doctors every year beginning in the late 90's.

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